解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Functioning and disability are universal human experiences. However, our current understanding of functioning from a comprehensive perspective is limited. The development of the International Classification of Functioning, Disability and Health (ICF) on the one hand and recent developments in graphical model...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-10-14
更新日期:2010-02-11 00:00:00
abstract:BACKGROUND:There is increasing awareness that meta-analyses require a sufficiently large information size to detect or reject an anticipated intervention effect. The required information size in a meta-analysis may be calculated from an anticipated a priori intervention effect or from an intervention effect suggested b...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-9-86
更新日期:2009-12-30 00:00:00
abstract:BACKGROUND:Health researchers undertake studies which combine qualitative and quantitative methods. Little attention has been paid to the structural issues affecting this mixed methods approach. We explored the facilitators and barriers to undertaking mixed methods studies in health research. METHODS:Face-to-face semi...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-9-82
更新日期:2009-12-09 00:00:00
abstract:BACKGROUND:Collection of buccal cells from saliva for DNA extraction offers a less invasive and convenient alternative to venipuncture blood collection that may increase participation in genetic epidemiologic studies. However, dried blood spot collection, which is also a convenient method, offers a means of collecting ...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-9-76
更新日期:2009-11-13 00:00:00
abstract:BACKGROUND:Quantitative Microbial Risk Assessment (QMRA), a modelling approach, is used to assess health risks. Inputs into the QMRA process include data that characterise the intensity, frequency and duration of exposure to risk(s). Data gaps for water exposure assessment include the duration and frequency of urban no...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-9-72
更新日期:2009-11-09 00:00:00
abstract:BACKGROUND:Quantitative survey of research articles, as an application of bibliometrics, is an effective tool for grasping overall trends in various medical research fields. This type of survey has been also applied to infectious disease research; however, previous studies were insufficient as they underestimated artic...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-9-67
更新日期:2009-10-06 00:00:00
abstract:BACKGROUND:Due to early colonoscopy for some participants, interval-censored observations can be introduced into the data of a colorectal polyp prevention trial. The censoring could be dependent of risk of recurrence if the reasons of having early colonoscopy are associated with recurrence. This can complicate estimati...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-9-66
更新日期:2009-09-29 00:00:00
abstract:BACKGROUND:Multiple imputation (MI) provides an effective approach to handle missing covariate data within prognostic modelling studies, as it can properly account for the missing data uncertainty. The multiply imputed datasets are each analysed using standard prognostic modelling techniques to obtain the estimates of ...
journal_title:BMC medical research methodology
pub_type: 杂志文章,实务指引
doi:10.1186/1471-2288-9-57
更新日期:2009-07-28 00:00:00
abstract:BACKGROUND:Observational outcome studies of patients with obstructive sleep apnea (OSA) require adjustment for co-morbidity to produce valid results. The aim of this study was to evaluate whether the combination of administrative data and self-reported data provided a more complete estimate of co-morbidity among patien...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-9-50
更新日期:2009-07-15 00:00:00
abstract:BACKGROUND:Studies have shown that industry-sponsored meta-analyses of drugs lack scientific rigour and have biased conclusions. However, these studies have been restricted to certain medical specialities. We compared all industry-supported meta-analyses of drug-drug comparisons with those without industry support. ME...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-8-60
更新日期:2008-09-09 00:00:00
abstract:BACKGROUND:This paper focuses on measuring the efficiency and effectiveness of two diagramming methods employed in key informant interviews with clinicians and health care administrators. The two methods are 'participatory diagramming', where the respondent creates a diagram that assists in their communication of answe...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-8-53
更新日期:2008-08-08 00:00:00
abstract:BACKGROUND:The main objective of this paper is to compare different methods for predicting the levels of SO2 air pollution in oil and gas producing area of rural western Canada. Month-long average air quality measurements were collected over a two-year period (2001-2002) at multiple locations, with some side-by-side me...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-8-43
更新日期:2008-07-04 00:00:00
abstract:BACKGROUND:Self-administered questionnaires are becoming increasingly common in general practice. Much research has explored methods to increase response rates but comparatively few studies have explored the effect of questionnaire administration on reported answers. METHODS:The aim of this study was to determine the ...
journal_title:BMC medical research methodology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2288-8-42
更新日期:2008-06-27 00:00:00
abstract:BACKGROUND:Interventions in occupational health often target worksites rather than individuals. The objective of this paper is to describe the (lack of) stability in units of analysis in occupational health and safety intervention projects directed toward worksites. METHODS:A case study approach is used to describe na...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-8-39
更新日期:2008-06-13 00:00:00
abstract:BACKGROUND:To describe how frequently harm is reported in the abstract of high impact factor medical journals. METHODS: DESIGN AND POPULATION:We carried out a blinded structured review of a random sample of 363 Randomised Controlled Trials (RCTs) carried out on human beings, and published in high impact factor medica...
journal_title:BMC medical research methodology
pub_type: 信件,评审
doi:10.1186/1471-2288-8-14
更新日期:2008-03-27 00:00:00
abstract:BACKGROUND:The most commonly used survey methods are self-administered questionnaires, telephone interviews, and a mixture of both. But until now evidence out of randomised controlled trials as to whether patient responses differ depending on the survey mode is lacking. Therefore this study assessed whether patient res...
journal_title:BMC medical research methodology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2288-7-50
更新日期:2007-11-22 00:00:00
abstract:BACKGROUND:The choice between paper data collection methods and electronic data collection (EDC) methods has become a key question for clinical researchers. There remains a need to examine potential benefits, efficiencies, and innovations associated with an EDC system in a multi-center medical record review study. MET...
journal_title:BMC medical research methodology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2288-7-23
更新日期:2007-06-18 00:00:00
abstract:BACKGROUND:It is notoriously difficult to recruit patients to randomised controlled trials in primary care. This is particularly true when the disease process under investigation occurs relatively infrequently and must be investigated during a brief time window. Bell's palsy, an acute unilateral paralysis of the facial...
journal_title:BMC medical research methodology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2288-7-15
更新日期:2007-03-28 00:00:00
abstract:BACKGROUND:When multiple endpoints are of interest in evidence synthesis, a multivariate meta-analysis can jointly synthesise those endpoints and utilise their correlation. A multivariate random-effects meta-analysis must incorporate and estimate the between-study correlation (rhoB). METHODS:In this paper we assess ma...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-7-3
更新日期:2007-01-12 00:00:00
abstract:BACKGROUND:Missing data present a challenge to many research projects. The problem is often pronounced in studies utilizing self-report scales, and literature addressing different strategies for dealing with missing data in such circumstances is scarce. The objective of this study was to compare six different imputatio...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-6-57
更新日期:2006-12-13 00:00:00
abstract:BACKGROUND:Methods for describing one's confidence in the available evidence are useful for end-users of evidence reviews. Analysts inevitably make judgments about the quality, quantity consistency, robustness, and magnitude of effects observed in the studies identified. The subjectivity of these judgments in several a...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-6-52
更新日期:2006-10-19 00:00:00
abstract:BACKGROUND:A recent paper found that terminal digits of statistical values in Nature deviated significantly from an equiprobable distribution, indicating errors or inconsistencies in rounding. This finding, as well as the discovery that a large percentage of p values were inconsistent with reported test statistics, led...
journal_title:BMC medical research methodology
pub_type: 评论,杂志文章
doi:10.1186/1471-2288-6-45
更新日期:2006-09-13 00:00:00
abstract:BACKGROUND:Systematic reviews (SRs) must be of high quality. The purpose of our research was to compare the methodological and reporting quality of original versus updated Cochrane SRs to determine whether updating had improved these two quality dimensions. METHODS:We identified updated Cochrane SRs published in issue...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-6-27
更新日期:2006-06-13 00:00:00
abstract:BACKGROUND:The "real" effect size of a medical therapy is constant over time. In contrast, the effect size reported in randomised controlled trials (RCTs) may change over time because the sum of all kinds of bias influencing the reported effectiveness is not necessarily constant. As this would affect the validity of me...
journal_title:BMC medical research methodology
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2288-6-25
更新日期:2006-05-11 00:00:00
abstract:BACKGROUND:It has been demonstrated that the enclosure of money with a mailed questionnaire increases the response rate significantly. We evaluated scratch lottery tickets as an alternative to cash. METHODS:1500 randomly selected Norwegians between the ages of 40 and 65 years were sent a short questionnaire. 250 recei...
journal_title:BMC medical research methodology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2288-6-19
更新日期:2006-04-28 00:00:00
abstract:BACKGROUND:Most electronic search efforts directed at identifying primary studies for inclusion in systematic reviews rely on the optimal Boolean search features of search interfaces such as DIALOG and Ovid. Our objective is to test the ability of an Ultraseek search engine to rank MEDLINE records of the included studi...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-6-7
更新日期:2006-02-24 00:00:00
abstract:BACKGROUND:Postal self-completion questionnaires offer one of the least expensive modes of collecting patient based outcomes in health care research. The purpose of this review is to assess the efficacy of methods of increasing response to postal questionnaires in health care studies on patient populations. METHODS:Th...
journal_title:BMC medical research methodology
pub_type: 杂志文章,评审
doi:10.1186/1471-2288-6-5
更新日期:2006-02-23 00:00:00
abstract:BACKGROUND:Postal questionnaires are widely used to collect outcome data on participants. However, a poor response to questionnaires will reduce the statistical power of the study and may introduce bias. A meta analysis of ten trials offering study results, largely in the fields of education and marketing, was shown to...
journal_title:BMC medical research methodology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2288-5-34
更新日期:2005-10-26 00:00:00
abstract:BACKGROUND:Systematic reviewers seek to comprehensively search for relevant studies and summarize these to present the most valid estimate of intervention effectiveness. The more resources searched, the higher the yield, and thus time and costs required to conduct a systematic review. While there is an abundance of evi...
journal_title:BMC medical research methodology
pub_type: 杂志文章,评审
doi:10.1186/1471-2288-5-24
更新日期:2005-08-10 00:00:00
abstract:BACKGROUND:Outcomes collected in randomized clinical trials are observations of random variables that should be independent and identically distributed. However, in some trials, the patients are randomized more than once thus violating both of these assumptions. The probability of an event is not always the same when a...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-5-17
更新日期:2005-05-10 00:00:00
abstract:BACKGROUND:To determine if the search technique that is used to sample randomized controlled trial (RCT) manuscripts from a field of medical science can influence the measurement of the change in quality over time in that field. METHODS:RCT manuscripts in the field of brain injury were identified using two readily-ava...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-5-7
更新日期:2005-02-07 00:00:00
abstract:BACKGROUND:There is analytical potential for multiple cause of death data collected from death certificates. This study examines relationships of multiple causes of death as a function of factors available on the death certificate (demographics of decedent, place of death, type of certifier, disposal method, whether an...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-5-4
更新日期:2005-01-17 00:00:00
abstract:BACKGROUND:Typically, randomization software should allow users to exert control over the different aspects of randomization including block design, provision of unique identifiers and control over the format and type of program output. While some of these characteristics have been addressed by available software, none...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-4-26
更新日期:2004-11-09 00:00:00
abstract:BACKGROUND:The prevalence of Chronic Obstructive Pulmonary Disease (COPD) in many developed countries appears to be increasing. There is some evidence from Latin America that COPD is a growing cause of death, but information on prevalence is scant. It is possible that, due to the high frequency of smoking in these coun...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-4-15
更新日期:2004-06-17 00:00:00
abstract:BACKGROUND:Given an observed test statistic and its degrees of freedom, one may compute the observed P value with most statistical packages. It is unknown to what extent test statistics and P values are congruent in published medical papers. METHODS:We checked the congruence of statistical results reported in all the ...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-4-13
更新日期:2004-05-28 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine the standard tasks performed by clinical research coordinators (CRCs) in oncology clinical trials. METHODS:Forty-one CRCs were anonymously surveyed, using a four-page self-administered questionnaire focused on demographics, qualifications, and professional experien...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-4-6
更新日期:2004-03-25 00:00:00
abstract:BACKGROUND:Controlled clinical trials of health care interventions are either explanatory or pragmatic. Explanatory trials test whether an intervention is efficacious; that is, whether it can have a beneficial effect in an ideal situation. Pragmatic trials measure effectiveness; they measure the degree of beneficial ef...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-3-28
更新日期:2003-12-22 00:00:00
abstract:BACKGROUND:In the era of evidence based medicine, with systematic reviews as its cornerstone, adequate quality assessment tools should be available. There is currently a lack of a systematically developed and evaluated tool for the assessment of diagnostic accuracy studies. The aim of this project was to combine empiri...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-3-25
更新日期:2003-11-10 00:00:00
abstract:BACKGROUND:The Anglia Menorrhagia Education Study (AMES) is a randomized controlled trial testing the effectiveness of an education package applied to general practices. Binary data are available from two sources; general practitioner reported referrals to hospital, and referrals to hospital determined by independent a...
journal_title:BMC medical research methodology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/1471-2288-3-17
更新日期:2003-09-24 00:00:00
abstract:BACKGROUND:Disease registers aim to collect information about all instances of a disease or condition in a defined population of individuals. Traditionally methods of operating disease registers have required that notifications of cases be identified by unique identifiers such as social security number or national iden...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/1471-2288-3-1
更新日期:2003-01-06 00:00:00